Brand  (β version)

PDB ID: 4YRC

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Ligands
Code Name Style Show Link
0P6 2-aminoquinolin-8-ol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
HIS Histidine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4YRC   PDBj   RCSB PDB   PDBe
Header : Ligase/Ligase inhibitor
Title : Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 2-aminoquinolin-8-ol (Chem 89)
Release Data : 2015-08-12
Compound :
mol_id molecule chains
1 Histidyl-tRNA synthetase A
ec: 6.1.1.21
fragment: UNP residues 45-478
Source :
mol_id organism_scientific expression_system
1 Trypanosoma cruzi (strain CL Brener)  (taxid:353153) Escherichia coli  (taxid:469008)
strain: CL Brener
gene: Tc00.1047053507019.40
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: AVA0421
Authors : Koh, C.-Y., Hol, W.G.J.
Keywords : ligase, aminoacyl-tRNA synthetase, aaRS, HisRS, Trypanosoma cruzi, protein-inhibitor complex, Ligase-Ligase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.

Koh, C.Y.,Siddaramaiah, L.K.,Ranade, R.M.  et al.
(2015)  Acta Crystallogr. D Biol. Crystallogr.  71 : 1684 - 1698

PubMed: 26249349
DOI: 10.1107/S1399004715007683

Reaction

Chain : A
UniProt : Q4DA54 (Q4DA54_TRYCC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L- histidyl-tRNA(His) 6.1.1.21 ARBA:ARBA00001137
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