Brand  (β version)

PDB ID: 4YLQ

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Ligands
Code Name Style Show Link
0Z7 N-acetyl-D-phenylalanyl-N-[(2s,3s)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide PoSSuM
CA Calcium ion PoSSuM
POL N-propanol PoSSuM
TMA Tetramethylammonium ion PoSSuM
Non-standard Residues
Code Name Show
CGU Gamma-carboxy-glutamic acid
Glycosylation
Code Name Emphasize
BGC Beta-D-glucopyranose
FUC Alpha-L-fucopyranose
XYS Alpha-D-xylopyranose
Modification
Code Name Show

Structure summary

Code : 4YLQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor
Release Data : 2015-12-30
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII L Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
fragment: BLOOD COAGULATION FACTOR VIIA LIGHT CHAIN, UNP residues 61-212
mol_id molecule chains synonym
2 Coagulation factor VII H Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
fragment: UNP residues 213-466
mutation: [169-175] LQQSRKVGDSPN - EASFPGK
mol_id molecule chains synonym
3 Tissue factor T TF,Coagulation factor III,Thromboplastin
fragment: UNP residues 33-251
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: Kidney
tissue: Blood
gene: F7
expression_system_common: Chinese Hamster
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: plasmid
expression_system_plasmid: pQMCF-5
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
organ: Kidney
tissue: Blood
gene: F7
expression_system_common: Chinese Hamster
expression_system_cell_line: CHOEBNALT85
expression_system_vector_type: plasmid
expression_system_plasmid: pQMCF-5
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
tissue: Blood
gene: F3
expression_system_variant: Origami 2
expression_system_vector_type: plasmid
expression_system_plasmid: pET3a
Authors : Sorensen, A.B., Svensson, L.A., Gandhi, P.S.
Keywords : trypsin-fold, protein-protein complex, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.4000 Å )
Citation :

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen, A.B.,Madsen, J.J.,Svensson, L.A.  et al.
(2016)  J.Biol.Chem.  291 : 4671 - 4683

PubMed: 26694616
DOI: 10.1074/jbc.M115.698613

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : T
UniProt : P13726
Reaction : -