Brand  (β version)

PDB ID: 4YK0

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986 (4r)-4-methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-one PoSSuM
EDO 1,2-ethanediol PoSSuM

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Structure summary

Code : 4YK0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the CBP bromodomain in complex with CPI098
Release Data : 2016-04-20
Compound :
mol_id molecule chains
1 CREB-binding protein A,B,C,D
ec: 2.3.1.48
fragment: bromodomain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
expression_system_vector_type: plasmid
Authors : Bellon, S.F., Jayaram, H.
Keywords : CBP, CPI098, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.6500 Å )
Citation :

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.

Ghosh, S.,Taylor, A.,Chin, M.  et al.
(2016)  J.Biol.Chem.  291 : 13014 - 13027

PubMed: 27056325
DOI: 10.1074/jbc.M115.708560

Reaction

Chain : A, B, C, D
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:21131905, PubMed:24616510
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L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826
(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L- lysyl-[protein] + CoA + H(+) - PubMed:38128537
left-to-right