Brand  (β version)

PDB ID: 4Y14

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
GOL Glycerol PoSSuM
C0A 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-nalpha-(methylsulfonyl)-L-phenylalaninamide PoSSuM
Non-standard Residues
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Structure summary

Code : 4Y14   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Release Data : 2015-08-05
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein phosphatase non-receptor type 1 A,B Protein-tyrosine phosphatase 1B,PTP-1B
ec: 3.1.3.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PTPN1, PTP1B
Authors : Choy, M.S., Connors, C., Page, R., Peti, W.
Keywords : Tyrosine inhibitor complex, HYDROLASE, PROTEIN BINDING, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8980 Å )
Citation :

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan, N.,Krishnan, K.,Connors, C.R.  et al.
(2015)  J.Clin.Invest.  125 : 3163 - 3177

PubMed: 26214522
DOI: 10.1172/JCI80323

Reaction

Chain : A, B
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE-ProRule:PRU10044
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