Brand  (β version)

PDB ID: 4XZL

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
F49 [2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl)-3,4-dihydropyrimidin-1(2h)-yl]acetic acid PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
Code Name Show
MLY N-dimethyl-lysine
MLZ N-methyl-lysine
Glycosylation
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Modification
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Structure summary

Code : 4XZL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human AKR1B10 complexed with NADP+ and JF0049
Release Data : 2015-11-18
Compound :
mol_id molecule chains synonym
1 Aldo-keto reductase family 1 member B10 X ARL-1,Aldose reductase-like,Aldose reductase-related protein,hARP,Small intestine reductase,SI reductase
ec: 1.1.1.-
mutation: K125R/V301L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AKR1B10, AKR1B11
Authors : Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A.
Keywords : TIM barrel, Aldo-keto reductase 1B10, oxidoreductase, diabetes, Halogenated compound, Cytosolic
Exp. method : X-RAY DIFFRACTION ( 1.700 Å )
Citation :

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.

Ruiz, F.X.,Cousido-Siah, A.,Porte, S.  et al.
(2015)  Chemmedchem  10 : 1989 - 2003

PubMed: 26549844
DOI: 10.1002/cmdc.201500393

Reaction

Chain : X
UniProt : O60218 (AK1BA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+) 1.1.1.300 PubMed:12732097, PubMed:18087047
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9-cis-retinol + NADP(+) = 9-cis-retinal + NADPH + H(+) - PubMed:12732097, PubMed:18087047
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13-cis-retinol + NADP(+) = 13-cis-retinal + NADPH + H(+) - PubMed:12732097
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allyl alcohol + NADP(+) = acrolein + NADPH + H(+) 1.1.1.54 PubMed:19563777
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(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+) - PubMed:19013440
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a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + NADPH + H(+) - PubMed:19563777
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prenol + NADP(+) = 3-methyl-2-butenal + NADPH + H(+) - PubMed:19563777
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(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + NADPH + H(+) - PubMed:19563777
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(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + NADPH + H(+) - PubMed:19563777
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(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + NADPH + H(+) - PubMed:19013440
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4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + NADPH + H(+) - PubMed:19013440
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