Brand  (β version)

PDB ID: 4X55

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Ligands
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CTJ 1-({(2r)-2-[(1r)-1-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2h-1,3-thiazin-5-yl}methyl)pyridinium PoSSuM
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Structure summary

Code : 4X55   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of the class D Beta-Lactamase OXA-225 K82D in Acyl-Enzyme Complex with Ceftazidime
Release Data : 2015-03-11
Compound :
mol_id molecule chains synonym
1 Beta-lactamase OXA-225 A,B OXA-23 class D beta-lactamase
mutation: K82D
Source :
mol_id organism_scientific expression_system
1 Acinetobacter baumannii  (taxid:470) Escherichia coli  (taxid:469008)
gene: blaOXA-225, oxa23
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24a
Authors : Clasman, J.R., June, C.M., Powers, R.A., Leonard, D.A.
Keywords : Hydrolase, Carbapenemase, Antibiotic
Exp. method : X-RAY DIFFRACTION ( 1.941 Å )
Citation :

Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D beta-Lactamases from Acinetobacter baumannii.

Mitchell, J.M.,Clasman, J.R.,June, C.M.  et al.
(2015)  Biochemistry  54 : 1976 - 1987

PubMed: 25710192
DOI: 10.1021/bi501547k

Reaction

Chain : A, B
UniProt : G5DE28 (G5DE28_ACIBA)
Reaction : -