Het-PDB Navi2 (PDB: 4WB3)

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
MG	Magnesium ion	PoSSuM
ACT	Acetate ion	PoSSuM

Non-standard Residues
Code	Name	Show
0G	L-guanosine-5'-monophosphate
0C	L-cytidine-5'-monophosphate
0A	L-adenosine-5'-monophosphate
0U	L-uridine-5'-monophosphate
0DG	2'-deoxy-L-ribo-furanosyl guanine-5'-monophosphate
0DA	2'-deoxy-L-ribo-furanosyl adenosine-5'-monophosphate
0DC	2'-deoxy-L-ribo-furanosyl cytosine-5'-monophosphate

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
3KA	1-(2-deoxy-5-O-phosphono-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1h,3h)-dione

Download interaction data: 4WB3

Code :

4WB3 PDBj RCSB PDB PDBe

Header :

DNA-RNA HYBRID

Title :

Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin

Release Data :

2015-05-06

Compound :

mol_id	molecule	chains	synonym
1	Complement C5	A,B,C	Hemolytic complement

mol_id	molecule	chains
2	mixed L-RNA/L-DNA aptamer NOX-D20 (40-MER)	D,E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: C5, Hc expression_system_strain: Shuffle T7 Express expression_system_vector_type: plasmid expression_system_plasmid: pET32a

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Yatime, L., Maasch, C., Hoehlig, K., Klussmann, S., Vater, A., Andersen, G.R.

Keywords :

protein-RNA complex, mirror-image aptamer, G-quadruplex, complement anaphylatoxin, DNA-RNA hybrid

Exp. method :

X-RAY DIFFRACTION ( 2.000 Å )

Citation :

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Yatime, L.,Maasch, C.,Hoehlig, K. et al.
(2015) Nat Commun 6 : 6481 - 6481

PDB ID: 4WB3