Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9F9 N-[1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1h-benzimidazol-5-yl]-2-methoxybenzamide
EDO 1,2-ethanediol
Code : 4UYE
Header : TRANSCRIPTION
Title : BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-2-oxo-6-(piperidin-1- yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl-2-methoxybenzamide
Release Data : 2014-09-17
Compound :
mol_id molecule chains synonym
1 PEREGRIN A,B BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 1, PROTEIN BR140
fragment: BROMODOMAIN, UNP RESIDUES 622-738
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Chung, C., Bamborough, P., Demont, E.
Keywords : TRANSCRIPTION, INHIBITOR, HISTONE, EPIGENETIC READER, ANTAGONIST
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain.

Demont, E.H.,Bamborough, P.,Chung, C.W.  et al.
(2014)  Acs Med.Chem.Lett.  5 : 1190

PubMed: 25408830
DOI: 10.1021/ML5002932

Chain : A, B
UniProt : P55201 (BRPF1_HUMAN)
Reaction : -