Brand  (β version)

PDB ID: 4UWB

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
JVT N-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4UWB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Fibroblast growth factor receptor 1 kinase in complex with JK-P5
Release Data : 2015-09-02
Compound :
mol_id molecule chains synonym
1 FIBROBLAST GROWTH FACTOR RECEPTOR 1 A,B FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, BFGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE
ec: 2.7.10.1
fragment: KINASE DOMAIN, RESIDUES 458-765
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: STAR
expression_system_vector_type: PLASMID
expression_system_vector: PET28
Authors : Beeston, H., Tucker, J., Kankanala, J.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.31 Å )
Citation :

Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

Beeston, H.S.,Klein, T.,Norman, R.A.  et al.
(2021)  Rapid Commun Mass Spectrom  : e9130 - e9130

PubMed: 34038603
DOI: 10.1002/rcm.9130

Reaction

Chain : A, B
UniProt : P11362 (FGFR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:1379697, PubMed:15117958, PubMed:18480409, PubMed:19224897, PubMed:19665973, PubMed:20133753, PubMed:8622701
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