Brand  (β version)

PDB ID: 4URX

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Ligands
Code Name Style Show Link
FK1 6-bromo-1h-indole PoSSuM
FMT Formic acid PoSSuM
HXY 1-(4-bromobenzyl)pyrrolidine PoSSuM
Non-standard Residues
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Structure summary

Code : 4URX   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : The crystal structure of H-Ras and SOS in complex with ligands
Release Data : 2015-03-04
Compound :
mol_id molecule chains synonym
1 GTPASE HRAS R H-RAS-1, HA-RAS, TRANSFORMING PROTEIN P21, C-H-RAS, P21RAS, H-RAS
fragment: RESIDUES 1-166
mol_id molecule chains synonym
2 SON OF SEVENLESS HOMOLOG 1 S SOS-1, SON OF SEVENLESS-1
fragment: RESIDUES 564-1049
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Keywords : SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.49 Å )
Citation :

Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.

Winter, J.,Anderson, M.,Blades, K.  et al.
(2015)  J.Med.Chem.  58 : 2265

PubMed: 25695162
DOI: 10.1021/JM501660T

Reaction

Chain : R
UniProt : P01112 (RASH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:9020151
-
Chain : S
UniProt : Q07889 (SOS1_HUMAN)
Reaction : -