Brand  (β version)

PDB ID: 4UNQ

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Ligands
Code Name Style Show Link
H6D 4-[(R)-methylsulfinyl]-2-oxo-6-[3-(trifluoromethoxy)phenyl]-1,2-dihydropyridine-3-carbonitrile PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4UNQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Mtb TMK in complex with compound 36
Release Data : 2015-06-24
Compound :
mol_id molecule chains synonym
1 THYMIDYLATE KINASE A,B THYMIDINE MONOPHOSPHATE KINASE, DTMP KINASE, TMPK
ec: 2.7.4.9
fragment: RESIDUES 1-210
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:1773) ESCHERICHIA COLI  (taxid:562)
Authors : Read, J.A., Hussein, S., Gingell, H., Tucker, J.
Keywords : TRANSFERASE, TRANSFER (ATP TMP PHOSPHOTRANSFERASE), KINASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors.

Naik, M.,Raichurkar, A.,Bandodkar, B.S.  et al.
(2015)  J.Med.Chem.  58 : 753

PubMed: 25486447
DOI: 10.1021/JM5012947

Reaction

Chain : A, B
UniProt : F2GKC3
Reaction : -