Brand  (β version)

PDB ID: 4UM3

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Ligands
Code Name Style Show Link
09R 1-(6-bromopyridin-3-yl)-1,4-diazepane PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4UM3   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3920
Release Data : 2015-07-22
Compound :
mol_id molecule chains synonym
1 ACETYLCHOLINE BINDING PROTEIN A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,Q,R,T,U,V,W,X,Y,Z,a,b,c,d,e,f,g,h,i,j,k,l,m,n ACH-BINDING PROTEIN, ACHBP, ACETYLCHOLINE BINDING PROTEIN
mutation: YES
other_details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
mol_id molecule chains synonym
2 ACETYLCHOLINE BINDING PROTEIN P ACH-BINDING PROTEIN, ACHBP, ACETYLCHOLINE BINDING PROTEIN
mutation: YES
other_details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
mol_id molecule chains synonym
3 ACETYLCHOLINE BINDING PROTEIN S ACH-BINDING PROTEIN, ACHBP, ACETYLCHOLINE BINDING PROTEIN
mutation: YES
other_details: 1-(6-BROMOPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3920) BINDS AT THE INTERFACE OF EACH TWO MONOMERS
Source :
mol_id organism_scientific organism_common expression_system
1 LYMNAEA STAGNALIS  (taxid:6523) GREAT POND SNAIL SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC
mol_id organism_scientific organism_common expression_system
2 LYMNAEA STAGNALIS  (taxid:6523) GREAT POND SNAIL SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC
mol_id organism_scientific organism_common expression_system
3 LYMNAEA STAGNALIS  (taxid:6523) GREAT POND SNAIL SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC
Authors : Shahsavar, A., Kastrup, J.S., Balle, T., Gajhede, M.
Keywords : NICOTINIC ACETYLCHOLINE RECEPTOR, ION CHANNEL, RECEPTOR STOICHIOMETRY, CYS-LOOP RECEPTOR, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.703 Å )
Citation :

Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

Shahsavar, A.,Ahring, P.K.,Olsen, J.A.  et al.
(2015)  Mol.Pharmacol.  88 : 697

PubMed: 26180047
DOI: 10.1124/MOL.115.098061

Reaction

Chain : S
UniProt : P58154 (ACHP_LYMST)
Reaction : -