Brand  (β version)

PDB ID: 4UIY

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Ligands
Code Name Style Show Link
5V2 N-[1,1-bis(oxidanylidene)thian-4-yl]-5-methyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-C]pyridine-2-carboximidamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 4UIY   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(1,1-dioxo-1-thian-4-yl)- 5-methyl-4-oxo-7-3-(trifluoromethyl)phenyl-4H,5H-thieno-3,2-C- pyridine-2-carboximidamide
Release Data : 2015-04-22
Compound :
mol_id molecule chains synonym
1 BROMODOMAIN-CONTAINING PROTEIN 4 A PROTEIN HUNK1, HUMAN BRD4
fragment: N-TERMINAL BROMODOMAIN, RESIDUES 44-168
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Chung, C., Theodoulou, N.T., Bamborough, P., Humphreys, P.G.
Keywords : TRANSCRIPTION, INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, BRD4, BROMODOMAIN CONTAINING PROTEIN 4, ANTAGONIST
Exp. method : X-RAY DIFFRACTION ( 1.30 Å )
Citation :

The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Theodoulou, N.H.,Bamborough, P.,Bannister, A.J.  et al.
(2016)  J.Med.Chem.  59 : 1425

PubMed: 25856009
DOI: 10.1021/ACS.JMEDCHEM.5B00256

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -