Brand  (β version)

PDB ID: 4UI3

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
SO4 Sulfate ion PoSSuM
06R 2-[4-(trifluoromethyl)phenyl]-3h-quinazolin-4-one PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 4UI3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human tankyrase 2 in complex with TA-26
Release Data : 2016-04-13
Compound :
mol_id molecule chains synonym
1 TANKYRASE-2 A,B TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD6, POLY [ADP-RIBOSE] POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN
ec: 2.4.2.30
fragment: C-TERMINAL FRAGMENT, RESIDUES 946-1113
mol_id molecule chains synonym
2 TANKYRASE-2 C,D TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD6, POLY [ADP-RIBOSE] POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN
ec: 2.4.2.30
fragment: C-TERMINAL FRAGMENT, RESIDUES 1115-1162
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA 2
expression_system_plasmid: PNIC28-BSA4
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_variant: ROSETTA 2
expression_system_plasmid: PNIC28-BSA4
Authors : Haikarainen, T., Lehtio, L.
Keywords : TRANSFERASE, DIPHTHERIA TOXIN LIKE FOLD, ADP- RIBOSYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases.

Nathubhai, A.,Haikarainen, T.,Hayward, P.C.  et al.
(2016)  Eur.J.Med.Chem.  118 : 316

PubMed: 27163581
DOI: 10.1016/J.EJMECH.2016.04.041

Reaction

Chain : C, D
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
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L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
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L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
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