Brand  (β version)

PDB ID: 4UDD

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Ligands
Code Name Style Show Link
CPS 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate PoSSuM
CV7 Desisobuytyryl ciclesonide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4UDD   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : GR in complex with desisobutyrylciclesonide
Release Data : 2015-11-25
Compound :
mol_id molecule chains synonym
1 GLUCOCORTICOID RECEPTOR A GR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1
fragment: LIGAND BINDING DOMAIN, UNP RESIDUES 500-777
mutation: YES
mol_id molecule chains synonym
2 NUCLEAR RECEPTOR COACTIVATOR 2 B NCOA-2, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 75, BHLHE75, TRANSCRIPTIONAL INTERMEDIARY FACTOR 2, HTIF2, NCOA2
fragment: RESIDUES 740-753
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN TRICHOPLUSIA NI  (taxid:7111)
expression_system_common: CABBAGE LOOPER
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC1
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Keywords : SIGNALING PROTEIN, NUCLEAR HORMONE RECEPTOR, LIGAND COMPLEX, PEPTIDE COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.

Edman, K.,Hosseini, A.,Bjursell, M.K.  et al.
(2015)  Structure  23 : 2280

PubMed: 26602186
DOI: 10.1016/J.STR.2015.09.012

Reaction

Chain : A
UniProt : P04150 (GCR_HUMAN)
Reaction : -
Chain : B
UniProt : Q15596 (NCOA2_HUMAN)
Reaction : -