Brand  (β version)

PDB ID: 4U75

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
GOL Glycerol PoSSuM
K Potassium ion PoSSuM
MET Methionine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4U75   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HsMetAP (F309M) in complex with Methionine
Release Data : 2015-03-25
Compound :
mol_id molecule chains synonym
1 Methionine aminopeptidase 1 A MetAP 1,Peptidase M 1
ec: 3.4.11.18
fragment: UNP residues 81-386
mutation: F309M
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: METAP1, KIAA0094
Authors : Arya, T., Addlagatta, A.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases

Arya, T.,Reddi, R.,Kishor, C.  et al.
(2015)  J.Med.Chem.  58 : 2350 - 2357

PubMed: 25699713
DOI: 10.1021/jm501790e

Reaction

Chain : A
UniProt : P53582 (MAP11_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03174, PubMed:17114291
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