Het-PDB Navi2 (PDB: 4SLI)

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Ligands
Code	Name		Style	Show	Link
CNP	2-propenyl-N-acetyl-neuraminic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 4SLI

Code :

4SLI PDBj RCSB PDB PDBe

Header :

ENZYME

Title :

LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2-PROPENYL-NEU5AC, AN INACTIVE SUBSTRATE ANALOGUE

Release Data :

1999-05-25

Compound :

mol_id	molecule	chains
1	INTRAMOLECULAR TRANS-SIALIDASE	A
	ec: 3.2.1.18 fragment: DEVOID OF N-TERMINAL 28 RESIDUES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Macrobdella decora (taxid:6405)	North American leech	Escherichia coli BL21(DE3) (taxid:469008)
	gene: T7 expression_system_strain: BL21 expression_system_variant: DE3 expression_system_vector_type: PLASMID expression_system_vector: PET 15B expression_system_plasmid: E2-M10 expression_system_gene: T7

Authors :

Luo, Y., Li, S.C., Li, Y.T., Luo, M.

Keywords :

ENZYME, INTRAMOLECULAR TRANS-SIALIDASE

Exp. method :

X-RAY DIFFRACTION ( 1.8 Å )

Citation :

The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.

Luo, Y.,Li, S.C.,Li, Y.T. et al.
(1999) J.Mol.Biol. 285 : 323 - 332

Chain :

UniProt :

Q27701 (NANL_MACDE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate.	4.2.2.15	-
	-	-

PDB ID: 4SLI