Het-PDB Navi2 (PDB: 4RQX)

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Ligands
Code	Name		Style	Show	Link
COM	1-thioethanesulfonic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4RQX

Code :

4RQX PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of human peroxiredoxin 4(THIOREDOXIN PEROXIDASE) with MESNA

Release Data :

2015-04-01

Compound :

mol_id	molecule	chains	synonym
1	Peroxiredoxin-4	A,B,C,D,E	Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372
	ec: 1.11.1.15 fragment: UNP residues 79-271

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: PRDX4 expression_system_strain: BL21

Authors :

Badger, J., Sridhar, V., Logan, C., Hausheer, F.H., Nienaber, V.L.

Keywords :

PEROXIREDOXIN, THIOREDOXIN, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.256 Å )

Citation :

Cysteine Specific Targeting of the Functionally Distinct Peroxiredoxin and Glutaredoxin Proteins by the Investigational Disulfide BNP7787.

Parker, A.R.,Petluru, P.N.,Nienaber, V.L. et al.
(2015) Molecules 20 : 4928 - 4950

Chain :

A, B, C, D, E

UniProt :

Q13162 (PRDX4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O	1.11.1.24	PubMed:21916849, PubMed:9388242
	-	PubMed:21916849, PubMed:9388242

PDB ID: 4RQX