Het-PDB Navi2 (PDB: 4R8I)

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Ligands
Code	Name	Link
K	Potassium ion	PoSSuM
NA	Sodium ion	PoSSuM
SR	Strontium ion	PoSSuM

Non-standard Residues
Code	Name	Show
0A	L-adenosine-5'-monophosphate
0C	L-cytidine-5'-monophosphate
0G	L-guanosine-5'-monophosphate
0U	L-uridine-5'-monophosphate
0U1	2'-methylselenyl-2'-deoxy-L-uridine-5'-monophosphate

Glycosylation
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Modification
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Download interaction data: 4R8I

Code :

4R8I PDBj RCSB PDB PDBe

Header :

Cytokine/RNA

Title :

High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2

Release Data :

2015-04-29

Compound :

mol_id	molecule	chains	synonym
1	C-C motif chemokine 2	A	HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2

mol_id	molecule	chains
2	Mirror-Image RNA Oligonucleotide Aptamer NOXE36	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CCL2, MCP1, SCYA2

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes other_details: The NOX-E36 L-oligonucleotides with the sequence 5'-GCACGUCCCUCACCGGUGCAAGUGAAGCCGUGGCUCUGCG-3' were synthesized using standard phosphoramidite chemistry at NOXXON Pharma AG (Berlin, Germany)

Authors :

Oberthuer, D., Achenbach, J., Gabdulkhakov, A., Falke, S., Buchner, K., Maasch, C., Rehders, D., Klussmann, S., Betzel, C.

Keywords :

Aptamer Spiegelmer L-oligonucleotide, Cytokine-RNA complex

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.

Oberthur, D.,Achenbach, J.,Gabdulkhakov, A. et al.
(2015) Nat Commun 6 : 6923 - 6923

PDB ID: 4R8I