Het-PDB Navi2 (PDB: 4R3M)

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Ligands
Code	Name		Style	Show	Link
JR9	N~3~-benzyl-2-[(6-bromo-1,3-benzodioxol-5-yl)methyl]imidazo[1,2-a]pyrazine-3,8-diamine				PoSSuM

Non-standard Residues
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Download interaction data: 4R3M

Code :

4R3M PDBj RCSB PDB PDBe

Header :

Chaperone/Chaperone Inhibitor

Title :

Crystal structure of Human Hsp90 with JR9

Release Data :

2014-11-05

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa, HSP 86, HSP86, Lipopolysaccharide-associated protein 2, LAP-2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
	fragment: UNP RESIDUES 16-223

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90A, HSP90AA1, HSPC1, HSPCA

Authors :

Li, J., Yang, M., Ren, J., Xiong, B., He, J.

Keywords :

Chaperone/Chaperone Inhibitor, Chaperone-Chaperone Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.800 Å )

Citation :

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity.

Ren, J.,Yang, M.,Liu, H. et al.
(2015) Org.Biomol.Chem. 13 : 1531 - 1535

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4R3M