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Ligands
Code Name Style Show Link
GOL Glycerol
JD1 [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid)
MG Magnesium ion
Non-standard Residues
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Code : 4PVY   PDBj   RCSB PDB   PDBe
Header : Transferase/transferase inhibitor
Title : Crystal structure of human FPPS in complex with [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid)
Release Data : 2015-04-15
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase F FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FDPS, FPS, KIAA1293
Authors : Rodionov, D., Park, J., De Schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
Keywords : Transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park, J.,Rodionov, D.,De Schutter, J.W.  et al.
(2017)  PLoS ONE  12 : e0186447 - e0186447

PubMed: 29036218
DOI: 10.1371/journal.pone.0186447

Chain : F
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
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