Brand  (β version)

PDB ID: 4PV0

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CG4 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4PV0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor
Release Data : 2014-05-21
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase, p72-Syk
ec: 2.7.10.2
fragment: Syk kinase domain, UNP residues 363-635
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SYK
Authors : Lansdon, E.B., Mitchell, S.A.
Keywords : Syk, spleen tyrosine kinase, kinase inhibitor, protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase.

Currie, K.S.,Kropf, J.E.,Lee, T.  et al.
(2014)  J.Med.Chem.  57 : 3856 - 3873

PubMed: 24779514
DOI: 10.1021/jm500228a

Reaction

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
-