Het-PDB Navi2 (PDB: 4OTH)

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Ligands
Code	Name		Style	Show	Link
DRN	Bisindolylmaleimide ix				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 4OTH

Code :

4OTH PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220

Release Data :

2014-08-27

Compound :

mol_id	molecule	chains	synonym
1	Serine/threonine-protein kinase N1	A	Protease-activated kinase 1, PAK-1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, Serine-threonine protein kinase N
	ec: 2.7.11.13 fragment: UNP residues 605-942

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: PKN1, PAK1, PKN, PRK1, PRKCL1

Authors :

Chamberlain, P.P., Delker, S., Pagarigan, B., Mahmoudi, A., Jackson, P., Abbassian, M., Muir, J., Raheja, N., Cathers, B.

Keywords :

PRK1, PKN1, Protein kinase C related kinase 1, KINASE, PROTEIN KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.8000 Å )

Citation :

Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.

Chamberlain, P.,Delker, S.,Pagarigan, B. et al.
(2014) Plos One 9 : e103638 - e103638

Chain :

UniProt :

Q16512 (PKN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.13	PubMed:18066052
	-	PubMed:18066052
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.13	PubMed:18066052
	-	PubMed:18066052

PDB ID: 4OTH