Brand  (β version)

PDB ID: 4OR2

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
FM9 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide PoSSuM
OLA Oleic acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4OR2   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Release Data : 2014-03-19
Compound :
mol_id molecule chains synonym
1 Soluble cytochrome b562, Metabotropic glutamate receptor 1 A,B Cytochrome b-562, mGluR1
mutation: M7W, H102I, R106L
other_details: Chimera protein of Soluble cytochrome b562 from Escherichia coli (P0ABE7) and residues 581-860 from Metabotropic glutamate receptor 1 from Homo sapiens (Q13255).
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: cybC, GRM1_HUMAN, GPRC1A, GRM1, MGLUR1
expression_system_strain: sf9
expression_system_vector_type: baculovirus
expression_system_plasmid: pFASTBAC
Authors : Wu, H., Wang, C., Gregory, K.J., Han, G.W., Cho, H.P., Xia, Y., Niswender, C.M., Katritch, V., Cherezov, V., Conn, P.J., Stevens, R.C., GPCR Network (GPCR)
Keywords : Human metabotropic glutamate receptor 1, allosteric modulator, novel protein engineering, GPCR network, membrane protein, PSI-Biology, Structural Genomics, GPCR, membrane, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator

Wu, H.,Wang, C.,Gregory, K.J.  et al.
(2014)  Science  344 : 58 - 64

PubMed: 24603153
DOI: 10.1126/science.1249489

Reaction

Chain : A, B
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -
Chain : A, B
UniProt : Q13255 (GRM1_HUMAN)
Reaction : -