Het-PDB Navi2 (PDB: 4OQM)

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Ligands
Code	Name		Style	Show	Link
FDU	1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethynylpyrimidine-2,4(1h,3h)-dione				PoSSuM
SO4	Sulfate ion				PoSSuM

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Download interaction data: 4OQM

Code :

4OQM PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU

Release Data :

2014-08-13

Compound :

mol_id	molecule	chains
1	Thymidine kinase	A,B
	ec: 2.7.1.21 fragment: UNP residues 45-376

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Human herpesvirus 1 (taxid:10299)	HHV-1	Escherichia coli (taxid:511693)
	strain: 17 gene: TK, TK (UL23), UL23 expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pGEX-6P-2

Authors :

Pernot, L., Neef, A.B., Westermaier, Y., Perozzo, R., Luedtke, N., Scapozza, L.

Keywords :

DNA SYNTHESIS, THYMIDINE KINASE, ATP-BINDING, NUCLEOTIDE-BINDING, TRANSFERASE, 5-ETHYNYLURIDINE NUCLEOSIDE DERIVATIVE

Exp. method :

X-RAY DIFFRACTION ( 2.200 Å )

Citation :

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU

Pernot, L.,Neef, A.B.,Westermaier, Y. et al.
To be Published

Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides.

Neef, A.B.,Luedtke, N.W.
(2011) Proc.Natl.Acad.Sci.USA 108 : 20404 - 20409

PDB ID: 4OQM