Brand  (β version)

PDB ID: 4NJV

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Ligands
Code Name Style Show Link
RIT Ritonavir PoSSuM
Non-standard Residues
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Structure summary

Code : 4NJV   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with ritonavir
Release Data : 2014-04-02
Compound :
mol_id molecule chains
1 Protease A,B,C,D
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
gene: pol
Authors : Yedidi, R.S., Garimella, H., Chang, S.B., Kaufman, J.D., Das, D., Wingfield, P.T., Mitsuya, H.
Keywords : multidrug-resistance, HIV-1 protease, ritonavir, RIT, protease inhibitor, kaletra, Hydrolase-Hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.

Yedidi, R.S.,Garimella, H.,Aoki, M.  et al.
(2014)  Antimicrob.Agents Chemother.  58 : 3679 - 3688

PubMed: 24752271
DOI: 10.1128/AAC.00107-14

Reaction

Chain : A, B, C, D
UniProt : Q9J006 (Q9J006_9HIV1)
Reaction : -