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Ligands
Code Name Style Show Link
CA Calcium ion
CL Chloride ion
J42 N-{[(1s)-5-({[4-bromo-2-({4,44-dioxo-48-[(3as,4s,6ar)-2-oxohexahydro-1h-thieno[3,4-D]imidazol-4-yl]-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-3,43-diazaoctatetracont-1-yl}oxy)phenyl]carbamoyl}amino)-1-carboxypentyl]carbamoyl}-L-glutamic acid
NA Sodium ion
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 4NGT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Release Data : 2014-06-18
Compound :
mol_id molecule chains synonym
1 Glutamate carboxypeptidase 2 A Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase
ec: 3.4.17.21
fragment: Extracellular domain, UNP residues 44-750
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
gene: FOLH, FOLH1, GIG27, NAALAD1, PSM, PSMA
expression_system_cell_line: SCHNEIDER 2(S2) CELLS
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: pMT/Bip
Authors : Tykvart, J., Pachl, P.
Keywords : hydrolase, glutamate carboxypeptidase II, PSMA, NAALADASE, urea-based inhibitor, caboxypeptidase, glycoprotein, metallopeptidase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3100 Å )
Citation :

Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.

Tykvart, J.,Schimer, J.,Barinkova, J.  et al.
(2014)  Bioorg.Med.Chem.  22 : 4099 - 4108

PubMed: 24954515
DOI: 10.1016/j.bmc.2014.05.061

Chain : A
UniProt : Q04609 (FOLH1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. 3.4.17.21 -
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