Brand  (β version)

PDB ID: 4MVX

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
MET Methionine PoSSuM
Non-standard Residues
Code Name Show
CAS S-(dimethylarsenic)cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4MVX   PDBj   RCSB PDB   PDBe
Header : LIGASE/LIGASE INHIBITOR
Title : Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea (Chem 1356)
Release Data : 2014-04-30
Compound :
mol_id molecule chains
1 Methionyl-tRNA synthetase A,B
ec: 6.1.1.10
fragment: UNP residues 237-773
mutation: K456A, K457R, E458A
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei  (taxid:5691) Escherichia coli  (taxid:469008)
gene: Tb10.70.6470
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: AVA0421
Authors : Koh, C.Y., Kim, J.E., Wetzel, A.B., de van der Schueren, W.J., Shibata, S., Liu, J., Zhang, Z., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Keywords : aminoacyl-tRNA synthetase, aaRS, MetRS, parasite, protein-inhibitor complex, Rossmann fold, translation, nucleotide binding, LIGASE-LIGASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.550 Å )
Citation :

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.

Koh, C.Y.,Kim, J.E.,Wetzel, A.B.  et al.
(2014)  Plos Negl Trop Dis  8 : e2775 - e2775

PubMed: 24743796
DOI: 10.1371/journal.pntd.0002775

Reaction

Chain : A, B
UniProt : Q38C91 (Q38C91_TRYB2)
Reaction : -