Brand  (β version)

PDB ID: 4MTZ

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
0BU 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4MTZ   PDBj   RCSB PDB   PDBe
Header : LIGASE/LIGASE INHIBITOR
Title : Structure of XIAP-BIR1 in complex with NF023
Release Data : 2014-09-24
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase XIAP A,B,C,D Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP
ec: 6.3.2.-
fragment: UNP residues 10-99
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: XIAP, API3, BIRC4, IAP3
Authors : Cossu, F., Milani, M., Grassi, S., Mastrangelo, E., Bolognesi, M.
Keywords : BIR domain, Anti-apoptotic, TAB1, LIGASE-LIGASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Protein-protein interactions in nfkb pathway: novel tools to promote apoptosis in cancer therapy

Cossu, F.,Milani, M.,Grassi, S.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : P98170 (XIAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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