Het-PDB Navi2 (PDB: 4M8T)

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Ligands
Code	Name		Style	Show	Link
NA	Sodium ion				PoSSuM
RMM	(2e)-2-cyano-3-[3-(1h-pyrazol-4-yl)phenyl]prop-2-enamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4M8T

Code :

4M8T PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

RSK2 T493M C-Terminal Kinase Domain in complex with 3-(3-(1H-pyrazol-4-yl)phenyl)-2-cyanoacrylamide

Release Data :

2014-10-22

Compound :

mol_id	molecule	chains	synonym
1	Ribosomal protein S6 kinase alpha-3	A	S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2
	ec: 2.7.11.1 fragment: RSK2 C-terminal Kinase Domain, UNP residues 400-720 mutation: T493M

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: Rps6ka3, Mapkapk1b, Rps6ka-rs1, Rsk2

Authors :

Miller, R.M., Taunton, J.

Keywords :

Protein Kinase, Phosphorylation, Covalent Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 3.000 Å )

Citation :

Covalent docking of large libraries for the discovery of chemical probes.

London, N.,Miller, R.M.,Krishnan, S. et al.
(2014) Nat.Chem.Biol. 10 : 1066 - 1072

Chain :

UniProt :

P18654 (KS6A3_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:15109498
	-	PubMed:15109498
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	-
	-	-

PDB ID: 4M8T