Het-PDB Navi2 (PDB: 4M48)

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Ligands
Code	Name	Link
21B	Nortriptyline	PoSSuM
CL	Chloride ion	PoSSuM
CLR	Cholesterol	PoSSuM
NA	Sodium ion	PoSSuM

Non-standard Residues
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Download interaction data: 4M48

Code :

4M48 PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

X-ray structure of dopamine transporter elucidates antidepressant mechanism

Release Data :

2013-09-18

Compound :

mol_id	molecule	chains	synonym
1	Transporter	A	dopamine transporter, GFP
	fragment: SEE REMARK 999 mutation: V74A V275A V311A L415A G538L, delta 1-20, delta 164-206, delta 603-631

mol_id	molecule	chains
2	9D5 antibody, light chain	L
	fragment: Fab, papain cleavage fragment

mol_id	molecule	chains
3	9D5 antibody, heavy chain	H
	fragment: Fab, papain cleavage fragment

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Drosophila melanogaster (taxid:7227)	Fruit fly	Homo sapiens (taxid:9606)
	gene: DAT, CG8380 expression_system_common: Human expression_system_cell_line: HEK

mol_id	organism_scientific
2	Mus musculus (taxid:10090)

mol_id	organism_scientific
3	Mus musculus (taxid:10090)

Authors :

Gouaux, E., Penmatsa, A., Wang, K.

Keywords :

SLC6, neurotransmitter transporter, TRANSPORT PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.955 Å )

Citation :

X-ray structure of dopamine transporter elucidates antidepressant mechanism.

Penmatsa, A.,Wang, K.H.,Gouaux, E.
(2013) Nature 503 : 85 - 90

PDB ID: 4M48