Brand  (β version)

PDB ID: 4LZ3

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Ligands
Code Name Style Show Link
BTM N-benzyl-N,N-diethylethanaminium PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
PI Hydrogenphosphate ion PoSSuM
POP Pyrophosphate 2- PoSSuM
Non-standard Residues
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Structure summary

Code : 4LZ3   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : F95H Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation
Release Data : 2013-12-18
Compound :
mol_id molecule chains synonym
1 Epi-isozizaene synthase A EIZS, Sesquiterpene cyclase, Sesquiterpene synthase
ec: 4.2.3.37
mutation: F95H
Source :
mol_id organism_scientific expression_system
1 Streptomyces coelicolor  (taxid:100226) Escherichia coli  (taxid:469008)
strain: A3(2)
gene: cyc1, SCO5222, SC7E4.19
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a(+)
Authors : Li, R., Chou, W., Himmelberger, J.A., Litwin, K., Harris, G., Cane, D.E., Christianson, D.W.
Keywords : LYASE, Class I terpene cyclase
Exp. method : X-RAY DIFFRACTION ( 2.095 Å )
Citation :

Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.

Li, R.,Chou, W.K.,Himmelberger, J.A.  et al.
(2014)  Biochemistry  53 : 1155 - 1168

PubMed: 24517311
DOI: 10.1021/bi401643u

Reaction

Chain : A
UniProt : Q9K499 (CYC1_STRCO)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate 4.2.3.37 -
-