Brand  (β version)

PDB ID: 4LRR

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Ligands
Code Name Style Show Link
CF9 2-oxo-2h-naphtho[1,8-bc]furan-6-yl 4-nitrobenzoate PoSSuM
SO4 Sulfate ion PoSSuM
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
Non-standard Residues
Code Name Show
SCH S-methyl-thio-cysteine
Glycosylation
Code Name Emphasize
Modification
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ACE Acetyl group

Structure summary

Code : 4LRR   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Ternary complex between E. coli thymidylate synthase, dUMP, and F9
Release Data : 2013-11-06
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A TS, TSase
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83334) Escherichia coli  (taxid:562)
strain: O157:H7
gene: thyA
Authors : Mangani, S., Pozzi, C., Ferrari, S., Costi, M.P.
Keywords : Thymidine monophosphate synthesis, N-terminal acetylated methionine, beta-mercaptoethanol modified cysteine, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.41 Å )
Citation :

2'-Deoxyuridine 5'-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives.

Ferrari, S.,Calo, S.,Leone, R.  et al.
(2013)  J.Med.Chem.  56 : 9356 - 9360

PubMed: 24147825
DOI: 10.1021/jm4014086

Reaction

Chain : A
UniProt : P0A886 (TYSY_ECO57)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008
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