Brand  (β version)

PDB ID: 4L3Q

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Ligands
Code Name Style Show Link
926 6-{3-[(1-methyl-1h-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1h)-one PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4L3Q   PDBj   RCSB PDB   PDBe
Header : Transferase/transferase activator
Title : Crystal structure of glucokinase-activator complex
Release Data : 2013-07-24
Compound :
mol_id molecule chains synonym
1 Glucokinase A Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
ec: 2.7.1.2
fragment: UNP residues 16-465
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GCK
Authors : Gajiwala, K.S., Filipski, K.J.
Keywords : Glycolysis, Diabetes, Transferase-transferase activator complex
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.

Filipski, K.J.,Guzman-Perez, A.,Bian, J.  et al.
(2013)  Bioorg.Med.Chem.Lett.  23 : 4571 - 4578

PubMed: 23831135
DOI: 10.1016/j.bmcl.2013.06.036

Reaction

Chain : A
UniProt : P35557 (HXK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+) 2.7.1.1 PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892
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ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+) 2.7.1.1 PubMed:7742312
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