Brand  (β version)

PDB ID: 4KWK

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Ligands
Code Name Style Show Link
CSS S-mercaptocysteine PoSSuM
FE2 Fe (II) ion PoSSuM
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Structure summary

Code : 4KWK   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Rat cysteine dioxygenase with cysteine persulfide bound to active site iron
Release Data : 2013-10-23
Compound :
mol_id molecule chains synonym
1 Cysteine dioxygenase type 1 A Cysteine dioxygenase type I, CDO, CDO-I
ec: 1.13.11.20
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats Escherichia coli  (taxid:469008)
gene: Cdo1
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: rCDO/pET32a
Authors : Souness, R.J., Wilbanks, S.M., Jameson, G.B., Jameson, G.N.L.
Keywords : non-heme, mono-iron, cupin, dioxygenase, cysteine-tyrosine crosslink, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase.

Souness, R.J.,Kleffmann, T.,Tchesnokov, E.P.  et al.
(2013)  Biochemistry  52 : 7606 - 7617

PubMed: 24084026
DOI: 10.1021/bi400661a

Reaction

Chain : A
UniProt : P21816 (CDO1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
L-cysteine + O2 = 3-sulfino-L-alanine + H(+) 1.13.11.20 PubMed:9824269
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