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Ligands
Code Name Style Show Link
DPO Diphosphate
MG Magnesium ion
PO4 Phosphate ion
SAM S-adenosylmethionine
Non-standard Residues
Code Name Show
MSE Selenomethionine
Glycosylation
Code Name Emphasize
Modification
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Code : 4K0B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAM and PPi
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 S-adenosylmethionine synthase A,B AdoMet synthase, Methionine adenosyltransferase
ec: 2.5.1.6
Source :
mol_id organism_scientific expression_system
1 Sulfolobus solfataricus  (taxid:273057) Escherichia coli  (taxid:562)
strain: P2
gene: mat, Ssol_1180
Authors : Wang, F., Hurley, K.A., Helmich, K.E., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Keywords : Structural Genomics, PSI-Biology, Protein Structure Initiative, Enzyme Discovery for Natural Product Biosynthesis, NatPro, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3900 Å )
Citation :

Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.

Wang, F.,Singh, S.,Zhang, J.  et al.
(2014)  Febs J.  281 : 4224 - 4239

PubMed: 24649856
DOI: 10.1111/febs.12784

Chain : A, B
UniProt : Q980S9 (METK_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O + L-methionine = diphosphate + phosphate + S- adenosyl-L-methionine 2.5.1.6 HAMAP-Rule:MF_00136
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