Brand  (β version)

PDB ID: 4JSL

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
QJ4 6,6'-heptane-1,7-diylbis(4-methylpyridin-2-amine) PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
CAS S-(dimethylarsenic)cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4JSL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)
Release Data : 2013-08-07
Compound :
mol_id molecule chains synonym
1 Nitric oxide synthase, endothelial A,B Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII
ec: 1.14.13.39
fragment: heme domain (UNP residues 40-482)
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:469008)
gene: NOS3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pCWori
Authors : Li, H., Poulos, T.L.
Keywords : nitric oxide synthase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.04 Å )
Citation :

In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.

Jing, Q.,Li, H.,Fang, J.  et al.
(2013)  Bioorg.Med.Chem.  21 : 5323 - 5331

PubMed: 23867386
DOI: 10.1016/j.bmc.2013.06.014

Reaction

Chain : A, B
UniProt : P29473 (NOS3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P29474
left-to-right