Het-PDB Navi2 (PDB: 4JS2)

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Ligands
Code	Name		Style	Show	Link
C	Cytidine-5'-monophosphate				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
BMA	Beta-D-mannopyranose
FUL	Beta-L-fucopyranose
GAL	Beta-D-galactopyranose
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 4JS2

Code :

4JS2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP

Release Data :

2013-07-31

Compound :

mol_id	molecule	chains	synonym
1	Beta-galactoside alpha-2,6-sialyltransferase 1	A	Alpha 2,6-ST 1, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1
	ec: 2.4.99.1 fragment: catalytic domain, UNP RESIDUES 89-406

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: ST6GAL1, SIAT1 expression_system_common: Human expression_system_cell_line: HEK 293

Authors :

Kuhn, B., Benz, J., Greif, M., Engel, A.M., Sobek, H., Rudolph, M.G.

Keywords :

Rossmann, GT-A, sialyltransferase, glycoprotein, sialylation, endoplasmatic reticulum, golgi, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.

Kuhn, B.,Benz, J.,Greif, M. et al.
(2013) Acta Crystallogr.,Sect.D 69 : 1826 - 1838

Chain :

UniProt :

P15907 (SIAT1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N- acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)	2.4.3.1	PubMed:21081508, PubMed:23999306
	-	PubMed:21081508, PubMed:23999306

PDB ID: 4JS2