Het-PDB Navi2 (PDB: 4JMO)

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Ligands
Code	Name		Style	Show	Link
JAF	N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4JMO

Code :

4JMO PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/INHIBITOR

Title :

Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide

Release Data :

2013-10-23

Compound :

mol_id	molecule	chains	synonym
1	Cytohesin-2	A	ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2
	fragment: Sec7 domain, UNP residues 56-251

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CYTH2, ARNO, PSCD2, PSCD2L expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: pET28-a

Authors :

Hoh, F., Rouhana, J.

Keywords :

Nucleotide exchange factor, ARF1, SIGNALING PROTEIN-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors

Rouhana, J.,Hoh, F.,Estaran, S. et al.
(2013) J.Med.Chem. 56 : 8497 - 8511

PDB ID: 4JMO