Brand  (β version)

PDB ID: 4J8M

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Ligands
Code Name Style Show Link
CJ5 1-[4-[[4-[(5-cyclopentyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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CAF S-dimethylarsinoyl-cysteine
Glycosylation
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Structure summary

Code : 4J8M   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Aurora A in complex with CD532
Release Data : 2014-09-10
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Meyerowitz, J.G., Gustafson, W.C., Shokat, K.M., Weiss, W.A.
Keywords : Aurora A, type II, kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.853 Å )
Citation :

Drugging MYCN through an Allosteric Transition in Aurora Kinase A.

Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A.  et al.
(2014)  Cancer Cell  26 : 414 - 427

PubMed: 25175806
DOI: 10.1016/j.ccr.2014.07.015

Reaction

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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