Brand  (β version)

PDB ID: 4HGL

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Ligands
Code Name Style Show Link
0YO 2-[5-methoxy-2-(quinolin-3-yl)pyrimidin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-C]pyridin-4-one PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4HGL   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : Crystal structure of ck1g3 with compound 1
Release Data : 2012-11-21
Compound :
mol_id molecule chains synonym
1 Casein kinase I isoform gamma-3 A CKI-gamma 3
ec: 2.7.11.1
fragment: unp residues 34-362
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK1G3
Authors : Huang, X.
Keywords : ck1g, kinase, inhibitor, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Structure-Based Design of Potent and Selective CK1 gamma Inhibitors.

Huang, H.,Acquaviva, L.,Berry, V.  et al.
(2012)  ACS Med Chem Lett  3 : 1059 - 1064

PubMed: 24900428
DOI: 10.1021/ml300278f

Reaction

Chain : A
UniProt : Q9Y6M4 (KC1G3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 -
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 -
-