Brand  (β version)

PDB ID: 4HAX

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
EDO 1,2-ethanediol PoSSuM
GNP Phosphoaminophosphonic acid-guanylate ester PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
RJA Ratjadone a, bound form PoSSuM
Non-standard Residues
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Structure summary

Code : 4HAX   PDBj   RCSB PDB   PDBe
Header : PROTEIN TRANSPORT/ANTIBIOTIC
Title : Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1
Release Data : 2013-01-09
Compound :
mol_id molecule chains synonym
1 Exportin-1 C CRM1, Chromosome region maintenance protein 1, Karyopherin-124
fragment: SEE REMARK 999
mutation: T539C,K579A,Y1022C
mol_id molecule chains synonym
2 GTP-binding nuclear protein Ran A Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein
mol_id molecule chains synonym
3 Ran-specific GTPase-activating protein 1 B Chromosome stability protein 20, Perinuclear array-localized protein, Ran-binding protein 1, RANBP1
fragment: RanDB1 (UNP residues 62-201)
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:4932) Yeast Escherichia coli  (taxid:562)
gene: CRM1, KAP124, XPO1, YGR218W, G8514
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: RAN, ARA24, OK/SW-cl.81
mol_id organism_scientific organism_common expression_system
3 Saccharomyces cerevisiae  (taxid:4932) Yeast Escherichia coli  (taxid:562)
gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
Authors : Sun, Q., Chook, Y.M.
Keywords : HEAT repeat, nuclear export, Ran-RanBP1, Ratjadone A, PROTEIN TRANSPORT-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Sun, Q.,Carrasco, Y.P.,Hu, Y.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 1303 - 1308

PubMed: 23297231
DOI: 10.1073/pnas.1217203110

Reaction

Chain : C
UniProt : P30822 (XPO1_YEAST)
Reaction : -
Chain : A
UniProt : P62826 (RAN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - PubMed:26272610, PubMed:8636225
left-to-right
Chain : B
UniProt : P41920 (YRB1_YEAST)
Reaction : -