Het-PDB Navi2 (PDB: 4H38)

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Ligands
Code	Name		Style	Show	Link
0YX	(5-bromo-2-{[3-(octyloxy)benzyl]oxy}phenyl)phosphonic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4H38

Code :

4H38 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297

Release Data :

2012-12-19

Compound :

mol_id	molecule	chains	synonym
1	Undecaprenyl pyrophosphate synthase	A,B	UPP synthase, Di-trans,poly-cis-decaprenylcistransferase, Ditrans,polycis-undecaprenyl-diphosphate synthase, Undecaprenyl diphosphate synthase, UDS
	ec: 2.5.1.31

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: uppS, ispU, rth, yaeS, b0174, JW0169

Authors :

Zhu, W., Oldfield, E.

Keywords :

prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.950 Å )

Citation :

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu, W.,Zhang, Y.,Sinko, W. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : 123 - 128

PubMed: 23248302
DOI: 10.1073/pnas.1219899110

Chain :

A, B

UniProt :

P60472 (UPPS_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di- trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate	2.5.1.31	-
	-	-

PDB ID: 4H38

Hetero Atom Contents

Structure summary

Reaction