Brand  (β version)

PDB ID: 4H38

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Ligands
Code Name Style Show Link
0YX (5-bromo-2-{[3-(octyloxy)benzyl]oxy}phenyl)phosphonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4H38   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297
Release Data : 2012-12-19
Compound :
mol_id molecule chains synonym
1 Undecaprenyl pyrophosphate synthase A,B UPP synthase, Di-trans,poly-cis-decaprenylcistransferase, Ditrans,polycis-undecaprenyl-diphosphate synthase, Undecaprenyl diphosphate synthase, UDS
ec: 2.5.1.31
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: uppS, ispU, rth, yaeS, b0174, JW0169
Authors : Zhu, W., Oldfield, E.
Keywords : prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.950 Å )
Citation :

Antibacterial drug leads targeting isoprenoid biosynthesis.

Zhu, W.,Zhang, Y.,Sinko, W.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 123 - 128

PubMed: 23248302
DOI: 10.1073/pnas.1219899110

Reaction

Chain : A, B
UniProt : P60472 (UPPS_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di- trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate 2.5.1.31 -
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:12756244
ECO:0000269 | PubMed:15044730
Binds 2 magnesium ions per subunit.