Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
CA Calcium ion
ZN Zinc ion
0Y3 N,N'-bis(4-{[(3r)-3-[(biphenyl-4-ylsulfonyl)(propan-2-yloxy)amino]-4-(hydroxyamino)-4-oxobutyl]amino}-4-oxobutyl)benzene-1,3-dicarboxamide
ACT Acetate ion
BCN Bicine
PEG Di(hydroxyethyl)ether
Code : 4H2E
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of an MMP twin inhibitor complexing two MMP-9 catalytic domains
Release Data : 2013-04-24
Compound :
mol_id molecule chains synonym
1 Matrix metalloproteinase-9 A,B MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B
ec: 3.4.24.35,3.4.24.35
fragment: unp residues 110-214 and 391-444
mutation: E402Q,E402Q
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MMP9, CLG4B
expression_system_strain: BL21 (DE3 star)
expression_system_vector_type: PT7 promoter
expression_system_plasmid: pET-14b
Authors : Stura, E.A., Vera, L., Cassar-Lajeunesse, E., Nuti, E., Catalani, M.P., Dive, V., Rossello, A.
Keywords : HYDROLASE/TWIN INHIBITOR, Zincin-like, Gelatinase, Collagenase (Catalytic Domain), HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.902 Å )
Citation :

Crystallization of bi-functional ligand protein complexes.

Antoni, C.,Vera, L.,Devel, L.  et al.
(2013)  J.Struct.Biol.  182 : 246 - 254

PubMed: 23567804
DOI: 10.1016/j.jsb.2013.03.015

Chain : A, B
UniProt : P14780 (MMP9_HUMAN)
Reaction : Cleavage of gelatin types I and V and collagen types IV and V.