Het-PDB Navi2 (PDB: 4H1J)

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Ligands
Code	Name		Style	Show	Link
0YH	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]urea				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4H1J

Code :

4H1J PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of PYK2 with the pyrazole 13a

Release Data :

2012-11-28

Compound :

mol_id	molecule	chains	synonym
1	Protein-tyrosine kinase 2-beta	A	PYK2, Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK
	ec: 2.7.10.2 fragment: protein kinase domain (UNP residues 416-692)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PTK2B, FAK2, PYK2, RAFTK expression_system_common: Fall armyworm

Authors :

Han, S.

Keywords :

kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.

Bhattacharya, S.K.,Aspnes, G.E.,Bagley, S.W. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 7523 - 7529

Chain :

UniProt :

Q14289 (FAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:15050747, PubMed:15166227, PubMed:18339875, PubMed:18951788, PubMed:19428251, PubMed:19648005
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PDB ID: 4H1J