Het-PDB Navi2 (PDB: 4GVH)

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Ligands
Code	Name		Style	Show	Link
MES	2-(N-morpholino)-ethanesulfonic acid				PoSSuM
0XY	5-fluoro-N-acetyl-alpha-D-glucosamine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4GVH

Code :

4GVH PDBj RCSB PDB PDBe

Header :

HYDROLASE/SUBSTRATE

Title :

Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) covalently bound to 5-fluoro-GlcNAc.

Release Data :

2012-12-19

Compound :

mol_id	molecule	chains	synonym
1	Beta-hexosaminidase	A,B	Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase
	ec: 3.2.1.52

Source :

mol_id	organism_scientific	expression_system
1	Salmonella enterica subsp. enterica serovar Typhimurium (taxid:99287)	Escherichia coli (taxid:562)
	strain: LT2 / SGSC1412 / ATCC 700720 gene: nagZ, STM1209

Authors :

Bacik, J.P., Mark, B.L.

Keywords :

TIM-BARREL, HYDROLASE, 5-F-GlcNAc, HYDROLASE-SUBSTRATE complex

Exp. method :

X-RAY DIFFRACTION ( 1.45 Å )

Citation :

Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.

Bacik, J.P.,Whitworth, G.E.,Stubbs, K.A. et al.
(2012) Chem.Biol. 19 : 1471 - 1482

Chain :

A, B

UniProt :

Q8ZQ06 (NAGZ_SALTY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.	3.2.1.52	HAMAP-Rule:MF_00364, PubMed:23177201, PubMed:24009110
	-	HAMAP-Rule:MF_00364, PubMed:23177201, PubMed:24009110

PDB ID: 4GVH