Brand  (β version)

PDB ID: 4GUB

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Ligands
Code Name Style Show Link
0Y4 N-[5-({3-cyano-7-[(1-methyl-1h-imidazol-4-yl)amino]pyrazolo[1,5-a]pyrimidin-5-yl}amino)-2-methylphenyl]acetamide PoSSuM
CL Chloride ion PoSSuM
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Structure summary

Code : 4GUB   PDBj   RCSB PDB   PDBe
Header : Transferase/transferase inhibitor
Title : Casein Kinase II bound to Inhibitor
Release Data : 2013-09-25
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
fragment: subunit alpha
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Larsen, N.A., Dowling, J.E.
Keywords : kinase, transferase, cytosol, Transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Potent and selective inhibitors of CK2 kinase.

Dowling, J.E.,Larsen, N.A.
To be Published 

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22017874, PubMed:22184066, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:31439799