Het-PDB Navi2 (PDB: 4GS0)

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Download interaction data: 4GS0

Code :

4GS0 PDBj RCSB PDB PDBe

Header :

HYDROLASE/TRANSFERASE

Title :

Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide

Release Data :

2012-12-19

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 6	A,B	Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1
	ec: 3.1.3.48 fragment: Phosphatase domain (UNP Residues 242-528)

mol_id	molecule	chains	synonym
2	Tyrosine-protein kinase JAK1	C	Janus kinase 1, JAK-1
	ec: 2.7.10.2 fragment: JAK1 activation loop phophomimetic (UNP Residues 1032-1037)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: HCP, PTP1C, PTPN6, SHP-1 expression_system_strain: Rosetta(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pET-32

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Alicea-Velazquez, N.L., Jakoncic, J., Boggon, T.J.

Keywords :

protein-protein complex, Phosphatase domain, Hydrolase, HYDROLASE-TRANSFERASE complex

Exp. method :

X-RAY DIFFRACTION ( 1.7961 Å )

Citation :

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.

Alicea-Velazquez, N.L.,Jakoncic, J.,Boggon, T.J.
(2013) J.Struct.Biol. 181 : 243 - 251

PDB ID: 4GS0