Brand  (β version)

PDB ID: 4GRB

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Ligands
Code Name Style Show Link
0XG 5-(2-{[4-(dimethylcarbamoyl)phenyl]amino}-4-methoxypyrimidin-5-yl)thiophene-3-carboxylic acid PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4GRB   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Casein kinase 2 (CK2) bound to inhibitor
Release Data : 2013-08-28
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
fragment: Transferase
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Larsen, N.A., Dowling, J.E., Ferguson, A.D.
Keywords : Kinase, Protein kinase, Cytosol, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.

Dowling, J.E.,Alimzhanov, M.,Bao, L.  et al.
(2013)  ACS Med Chem Lett  4 : 800 - 805

PubMed: 24900749
DOI: 10.1021/ml400197u

Reaction

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22017874, PubMed:22184066, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:28512243, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:31439799