Het-PDB Navi2 (PDB: 4GR1)

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Ligands
Code	Name	Link
FAD	Flavin-adenine dinucleotide	PoSSuM
PO4	Phosphate ion	PoSSuM
RGS	4n-malonyl-cysteinyl-2,4-diaminobutyrate disulfide	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4GR1

Code :

4GR1 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE (FLAVOENZYME)

Title :

THE BINDING OF THE RETRO-ANALOGUE OF GLUTATHIONE DISULFIDE TO GLUTATHIONE REDUCTASE

Release Data :

1991-10-15

Compound :

mol_id	molecule	chains
1	GLUTATHIONE REDUCTASE	A
	ec: 1.6.4.2

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Schulz, G.E., Janes, W.

Keywords :

OXIDOREDUCTASE (FLAVOENZYME)

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

The binding of the retro-analogue of glutathione disulfide to glutathione reductase.

Janes, W.,Schulz, G.E.
(1990) J.Biol.Chem. 265 : 10443 - 10445

PubMed: 2355009

Chain :

UniProt :

P00390 (GSHR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)	1.8.1.7	PubMed:17185460
	-	PubMed:17185460
Cofactor:	Evidence:	Note:
FAD	ECO:0000269 \| PubMed:16910673 ECO:0000269 \| PubMed:18638483 ECO:0000269 \| PubMed:2585516 ECO:0000269 \| PubMed:3656429 ECO:0000269 \| PubMed:8626496 ECO:0000269 \| PubMed:9174360 ECO:0000269 \| PubMed:9546215	Binds 1 FAD per subunit.

PDB ID: 4GR1